USP5 motivates immunosuppressive microenvironment in multiple myeloma by activating STAT2-PFKFB4-mediated glycolysis

Abstract Background Glycolysis, a classic characteristic of cancer cells, can drive cancer progression by generating lactate, which play as a key immunosuppressive mediator.Currently, ubiquitin-specific proteases 5 (USP5) has been demonstrated to facilitate tumor cell survival in multiple myeloma (MM), whereas whether USP5 was involved in glycolysi

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Deciphering the Dilemma: Choosing the Optimal Total Neoadjuvant Treatment Strategy for Locally Advanced Rectal Cancer

Rectal cancer management has evolved significantly, particularly with neoadjuvant treatment strategies.This narrative review examines the development and effectiveness of these therapies for locally advanced rectal cancer (LARC), highlighting the historical quest that led to current neoadjuvant alternatives.Initially, trials showed the benefits of

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Schizophrenia syndrome due to C9ORF72 mutation case report: a cautionary tale and role of hybrid brain imaging!

Abstract Background Frontal variant frontotemporal dementia is a common cause of presenile dementia.A hexanucleotide expansion on chromosome 9 has recently been recognized as the most common genetic mutation cause of this illness.This sub-type tends to present psychiatrically with psychosis being a common presenting symptom before the onset of cogn

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