Background:.Ear avulsion is a rare complication Bowls of different traumas, such as car accidents, human or animal bites and stab wounds, and can result in dramatic cosmetic consequences for the patient.Ear replantation, revascularization, and reattachment are the options offering best aesthetic results.But venous outflow insufficiency is responsib
USP5 motivates immunosuppressive microenvironment in multiple myeloma by activating STAT2-PFKFB4-mediated glycolysis
Abstract Background Glycolysis, a classic characteristic of cancer cells, can drive cancer progression by generating lactate, which play as a key immunosuppressive mediator.Currently, ubiquitin-specific proteases 5 (USP5) has been demonstrated to facilitate tumor cell survival in multiple myeloma (MM), whereas whether USP5 was involved in glycolysi
Deciphering the Dilemma: Choosing the Optimal Total Neoadjuvant Treatment Strategy for Locally Advanced Rectal Cancer
Rectal cancer management has evolved significantly, particularly with neoadjuvant treatment strategies.This narrative review examines the development and effectiveness of these therapies for locally advanced rectal cancer (LARC), highlighting the historical quest that led to current neoadjuvant alternatives.Initially, trials showed the benefits of
Intravenous thrombolysis with rt-PA in stroke: experience of the moroccan stroke unit
The majority of strokes are due to blockage of an artery in the brain by a blood clot.Prompt treatment with thrombolytic drugs can restore blood flow before major brain damage has occurred.We report the case series of all patients who were treated with rt-PA Bowls at Stroke Unit of HASSAN II University hospital between 2010 and 2013.There were 52 p
Schizophrenia syndrome due to C9ORF72 mutation case report: a cautionary tale and role of hybrid brain imaging!
Abstract Background Frontal variant frontotemporal dementia is a common cause of presenile dementia.A hexanucleotide expansion on chromosome 9 has recently been recognized as the most common genetic mutation cause of this illness.This sub-type tends to present psychiatrically with psychosis being a common presenting symptom before the onset of cogn